Here, we report a case of 70-year-old female with metastatic choroidal
melanoma in the liver, which was detected 30 years after enucleation of the left eyeball. At first, two hypovascular
tumors (4cm and 1cm in diameter) were detected in the liver as high-density areas on plain computed tomography (CT). They were demonstrated as hyper- and hypo-intensity lesions on T1- and T2-weighted image of magnetic resonance imaging (MRI), respectively, with superparamagnetic
iron oxide uptake. During about 2-years follow-up, the larger
tumor did not change significantly in size and in the character. However, the smaller one grew up in size and changed its nature to hypervascular and hyper-intensity on T2-weighted image of MRI. These hypervascular
tumors increased in number and in size rapidly. The specimens obtained with
tumor biopsy revealed epithelioid
tumor cells positive for HMB45 immunohistochemical
stain with and without brown pigment, and the
tumors were diagnosed as
melanoma. The patient underwent transcatheter arterial chemoembolization with
cisplatin and
epirubicin hydrochloride, and subsequent transcatheter arterial infusion
chemotherapy with
cisplatin,
nimustine and
dacarbazine. Unfortunately, however, the
tumor rapidly progressed and she died. We discuss the imaging of the
melanoma metastasized to the liver with the estimation of doubling time (DT) of the
tumors.