Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase.

Abstract

Digalactosyl and monogalactocyl diacylglycerols (DGDG and MGDG), which were identified as anti-hyperlipemia active components in Colocasia esculenta (Taro), were synthesized. The inhibitory activity of DGDG, MGDG and related compounds on human lanosterol synthase was evaluated as anti-hyperlipemic activity. DGDG with two myristoyl groups at both sn-1 and sn-2 positions and with an oleoyl group at the sn-1 position showed the most potent activity.

• Authors: Rie Tanaka, Yuichi Sakano, Akito Nagatsu, Masaaki Shibuya, Yutaka Ebizuka, Yukihiro Goda
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 15 Issue 1 Pg. 159-62 (Jan 03 2005) ISSN: 0960-894X [Print] England
• PMID: 15582431 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Enzyme Inhibitors
• Galactolipids
• digalactosyldiacylglycerol
• Intramolecular Transferases
• lanosterol synthase

Topics

• Carbohydrate Sequence
• Enzyme Inhibitors (chemical synthesis, chemistry, pharmacology)
• Galactolipids (chemical synthesis, chemistry, pharmacology)
• Humans
• Intramolecular Transferases (antagonists & inhibitors)
• Molecular Sequence Data
• Structure-Activity Relationship