Abstract | BACKGROUND: METHODS: Three hundred women of reproductive age who underwent RP/IPAA between 1983 and 2001 completed a mailed questionnaire regarding their reproductive function before and after the procedure. Additional information was obtained from the pelvic pouch database. The reproductive information was compared to age-matched historical control subjects from the United States general population. The associations between changes in fertility and surgical parameters were also investigated. RESULTS: The median (25th, 75th percentile) age at surgery was 28 (24, 33) years. Out of 300 women, 206 attempted to conceive. Before operation, 48 (38%) of 127 patients were unsuccessful after 1 year of unprotected intercourse, whereas after operation, 76 (56%) of 135 patients were unsuccessful. This infertility rate was higher after operation than before (P <.001). For the subgroup of 56 women who tried to get pregnant both before and after operation, the infertility rate was higher after operation than before (69% vs 46%; P=.005). Also, a higher percentage of these patients who had an intraoperative transfusion were infertile after operation compared to patients who did not have an intraoperative transfusion (54% vs 21%; P=.023). CONCLUSIONS: There was an increase in the infertility rate after RP/IPAA. Intraoperative blood transfusion had a negative impact on the fertility rate after operation in patients who tried to conceive both before and after RP/IPAA.
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Authors | Emre Gorgun, Feza H Remzi, Jeffrey M Goldberg, Julie Thornton, Jane Bast, Tracy L Hull, Bridget Loparo, Victor W Fazio |
Journal | Surgery
(Surgery)
Vol. 136
Issue 4
Pg. 795-803
(Oct 2004)
ISSN: 0039-6060 [Print] United States |
PMID | 15467664
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Adolescent
- Adult
- Birth Rate
- Colonic Pouches
(adverse effects, statistics & numerical data)
- Female
- Humans
- Infertility, Female
(epidemiology, etiology)
- Proctocolectomy, Restorative
(adverse effects, statistics & numerical data)
- United States
(epidemiology)
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