Influence of thiamphenicol on the primary functions of human polymorphonuclear leucocytes against Streptococcus pyogenes.

Abstract	Current antibiotic therapy encourages the use of antibiotics that may potentiate the host's immune defences. We therefore investigated the effect of thiamphenicol (TAP), the active principle of thiamphenicol glycinate acetylcysteinate (TGA), on human granulocyte functions, mainly phagocytosis and intracellular killing of Streptococcus pyogenes. Our findings support the use of thiamphenicol in the treatment of respiratory tract infections caused by S. pyogenes as it acts directly against the pathogen as well as in cooperation with PMNs by eliciting their intracellular killing.
Authors	Vivian Tullio, Annamaria Cuffini, Narcisa Mandras, Janira Roana, Giuliana Banche, Domenico Ungheri, Nicola Carlone
Journal	International journal of antimicrobial agents (Int J Antimicrob Agents) Vol. 24 Issue 4 Pg. 381-5 (Oct 2004) ISSN: 0924-8579 [Print] Netherlands
PMID	15380265 (Publication Type: Journal Article)
Chemical References	Anti-Bacterial Agents Thiamphenicol Phenylbutazone
Topics	Anti-Bacterial Agents (pharmacology) Humans Microbial Sensitivity Tests Neutrophils (drug effects, microbiology, physiology) Phenylbutazone (pharmacology) Staphylococcus aureus (drug effects, isolation & purification) Thiamphenicol (pharmacology)

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