Treatment of Behçet's disease with granulocyte and monocyte adsorption apheresis.

Abstract

The painful orogenital ulcerations of Behçet's disease are among the major symptoms of patients and are often intractable. We assessed the efficacy of granulocyte and monocyte adsorption apheresis therapy in two patients, a 21-year-old man with orogenital ulcerations and a 50-year-old woman with genital ulceration and abdominal pain. They underwent 5 and 8 granulocyte and monocyte adsorption apheresis treatments at 5-day intervals, respectively. The painful orogenital ulcerations of the man responded dramatically and the genital ulcer of the woman decreased in size and her abdominal pain was improved. Our results demonstrate that granulocyte and monocyte adsorption apheresis may be useful for treating orogenital ulcerations of Behçet's disease.

• Authors: Takuro Kanekura, Akira Gushi, Masahiro Iwata, Seita Fukumaru, Ryoko Sakamoto, Koichi Kawahara, Ikuro Maruyama, Tamotsu Kanzaki
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 51 Issue 2 Suppl Pg. S83-7 (Aug 2004) ISSN: 1097-6787 [Electronic] United States
• PMID: 15280820 (Publication Type: Case Reports, Journal Article)

Chemical References

• Macrophage-1 Antigen

Topics

• Adsorption
• Adult
• Behcet Syndrome (blood, diagnosis, therapy)
• Blood Component Removal (methods)
• Female
• Flow Cytometry
• Granulocytes (metabolism)
• Humans
• Macrophage-1 Antigen (metabolism)
• Male
• Middle Aged
• Monocytes (metabolism)
• Neutrophils (metabolism)
• Pain Measurement
• Remission Induction