CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis.

Abstract

The pathogenesis of relapsing neuromyelitis optica (RNMO) remains unknown. We, for the first time, studied the levels of four chemokines in the cerebrospinal fluid in RNMO with ELISA and compared the data with those in multiple sclerosis (MS) and control. CXCL10/IP-10 and CCL17/TARC were significantly elevated in both RNMO and MS. Conversely, CCL2/MCP-1 was significantly lower in MS, but not in RNMO, than in control. CCL11/Eotaxin was not different between groups. None of the four chemokines studied was significantly different between RNMO and MS.

• Authors: Koichi Narikawa, Tatsuro Misu, Kazuo Fujihara, Ichiro Nakashima, Shigeru Sato, Yasuto Itoyama
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 149 Issue 1-2 Pg. 182-6 (Apr 2004) ISSN: 0165-5728 [Print] Netherlands
• PMID: 15020078 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chemokines

Topics

• Age of Onset
• Chemokines (blood, cerebrospinal fluid)
• Enzyme-Linked Immunosorbent Assay (methods)
• Female
• Humans
• Male
• Multiple Sclerosis (blood, cerebrospinal fluid)
• Neuromyelitis Optica (blood, cerebrospinal fluid)
• Statistics, Nonparametric