Polo-like kinase 1 (PLK1) expression is associated with cell proliferative activity and cdc2 expression in malignant lymphoma of the thyroid.

Abstract

BACKGROUND:

Polo-like kinase 1 (PLK1) is one of the serine threonine kinases that plays a role in cellular proliferation by activating the CDC25C-CDK1 (cdc2) loop. We recently demonstrated that cdc2 expression is associated with the biological aggressiveness of malignant lymphoma of the thyroid. In this study, we investigated PLK1 expression in thyroid lymphoma in order to elucidate its physiological significance in this disease.

MATERIALS AND METHODS:

We immunohistochemically investigated PLK1 expression in 46 cases of thyroid lymphoma and 10 cases of chronic thyroiditis.

RESULTS:

Normal follicular cells did not express PLK1, whereas follicular cells in those in chronic thyroiditis and malignant lymphoma demonstrated a high level of PLK1 expression. In lymphocytes in chronic thyroiditis with strong lymphocyte infiltration, PLK1 was weakly expressed. In malignant lymphoma, PLK1 expression was observed in all cases, but PLK1 was more strongly expressed in cases with high cell proliferative activity and with cdc2 expression.

CONCLUSION:

These results suggest that PLK1 regulates the cell cycle progression of thyroid lymphoma cells in the G2-M-phase.

• Authors: Yasuhiro Ito, Hiroshi Yoshida, Fumio Matsuzuka, Nariaki Matsuura, Yasushi Nakamura, Hirokazu Nakamine, Kennichi Kakudo, Kanji Kuma, Akira Miyauchi
• Journal: Anticancer research (Anticancer Res) 2004 Jan-Feb Vol. 24 Issue 1 Pg. 259-63 ISSN: 0250-7005 [Print] Greece
• PMID: 15015605 (Publication Type: Journal Article)

Chemical References

• Cell Cycle Proteins
• Proto-Oncogene Proteins
• Protein Kinases
• Protein Serine-Threonine Kinases
• polo-like kinase 1
• CDC2 Protein Kinase

Topics

• CDC2 Protein Kinase (biosynthesis)
• Cell Cycle Proteins
• Cell Division (physiology)
• Humans
• Immunohistochemistry
• Lymphocytes (immunology)
• Lymphoma (enzymology, immunology, pathology)
• Protein Kinases (biosynthesis)
• Protein Serine-Threonine Kinases
• Proto-Oncogene Proteins
• Thyroid Neoplasms (enzymology, immunology, pathology)
• Thyroiditis, Autoimmune (enzymology, immunology, pathology)