Improvement of clinical and MRI findings in a boy with adrenoleukodystrophy by dietary erucic acid therapy.

Abstract

A 5-year-old boy with adrenoleukodystrophy, with clinical symptoms of visual, mental and motor disturbances which progressed rapidly, was treated with Lorenzo's oil consisting 1 volume of glyceryl trierucate and 4 volumes of glyceryl trioleate. Five months after initiation of this therapy, ability to swallow was enhanced and T2-weighted magnetic resonance imaging of the brain revealed regression of high intensity area of the parieto-occipital white matter.

• Authors: K Maeda, Y Suzuki, S Yajima, J Asano, S Yamaguchi, N Matsumoto, J Borel, H W Moser, T Orii
• Journal: Brain & development (Brain Dev) Vol. 14 Issue 6 Pg. 409-12 (Nov 1992) ISSN: 0387-7604 [Print] Netherlands
• PMID: 1492654 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dietary Fats, Unsaturated
• Drug Combinations
• Erucic Acids
• Lorenzo's oil
• Triolein

Topics

• Adrenoleukodystrophy (diet therapy, pathology, physiopathology)
• Brain (pathology)
• Child, Preschool
• Dietary Fats, Unsaturated (therapeutic use)
• Drug Combinations
• Erucic Acids (therapeutic use)
• Humans
• Magnetic Resonance Imaging
• Male
• Triolein (therapeutic use)