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Active and passive immunization for tetrodotoxin in mice.

Abstract
This study describes the possibility of active and passive immunization for tetrodotoxin (TTX) poisoning. TTX was conjugated to keyhole limpet hemocyanin and this conjugate was used as an immunogen in rabbits and mice. Mice immunized with the conjugate were protected from a lethal dose of TTX. Passive protection experiments demonstrated that immunoglobulin from rabbit antiserum exhibited a dose-related therapeutic activity in mice after challenge with TTX.
AuthorsS Fukiya, K Matsumura
JournalToxicon : official journal of the International Society on Toxinology (Toxicon) Vol. 30 Issue 12 Pg. 1631-4 (Dec 1992) ISSN: 0041-0101 [Print] England
PMID1488772 (Publication Type: Journal Article)
Chemical References
  • Immunoglobulin G
  • Serum Albumin, Bovine
  • Tetrodotoxin
Topics
  • Animals
  • Dose-Response Relationship, Drug
  • Immunity, Active
  • Immunization, Passive
  • Immunoglobulin G (immunology)
  • Mice
  • Serum Albumin, Bovine (immunology)
  • Tetrodotoxin (immunology, toxicity)

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