Abstract | OBJECTIVE: This study was undertaken to determine whether subchorionic endotoxin infusion causes chorioamnionitis and preterm lung maturation, as occurs after intra-amniotic endotoxin. STUDY DESIGN: From day 118 of pregnancy, sheep received infusions of endotoxin (subchorionic 7.5 mg/d, n=11; intra-amniotic 2.5 mg/d, n=9) until delivery of lambs at 120 or 124 days. Other sheep received a single intra-amniotic injection of endotoxin (10 mg, n=7) at 118 days before delivery at 124 days. Controls (n=9) received equivalent saline solution treatments. RESULTS: CONCLUSION:
Chorioamnionitis may result from inflammatory stimuli at various intrauterine sites, with different sites causing different fetal effects and not all cases of chorioamnionitis being accompanied by enhanced lung maturation.
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Authors | Timothy J M Moss, Ilias Nitsos, John P Newnham, Machiko Ikegami, Alan H Jobe |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 189
Issue 6
Pg. 1771-6
(Dec 2003)
ISSN: 0002-9378 [Print] United States |
PMID | 14710113
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Amnion
(drug effects)
- Amniotic Fluid
(chemistry)
- Analysis of Variance
- Animals
- Chorioamnionitis
(complications)
- Disease Models, Animal
- Embryonic and Fetal Development
(drug effects)
- Endotoxins
(pharmacology)
- Female
- Injections
- Pneumonia
(diagnosis)
- Pregnancy
- Pregnancy, Animal
- Probability
- Random Allocation
- Reference Values
- Sheep, Domestic
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