Abstract | OBJECTIVE: MATERIAL AND METHODS: RESULTS: Development of CSF-specific OB was found to occur, 6 weeks after immunization, in seven of 42 rats. OB was detected in rats with an antibody response against MBP, whereas as a role no such bands were present in rats with an antibody response against MOG. Initially severe disease symptoms were correlated to a concomitant intense oligoclonal antibody response. CONCLUSION: Cerebrospinal fluid-specific OB occurs in EAE. It is present in rats with an anti-MBP, but not in rats with an anti-MOG antibody response. A severe disease results in an intense oligoclonal antibody response, which might have an anti-inflammatory effect.
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Authors | B Rostrom, A Grubb, R Holmdahl |
Journal | Acta neurologica Scandinavica
(Acta Neurol Scand)
Vol. 109
Issue 2
Pg. 106-12
(Feb 2004)
ISSN: 0001-6314 [Print] Denmark |
PMID | 14705972
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoglobulin G
- Mog protein, rat
- Myelin Basic Protein
- Myelin Proteins
- Myelin-Associated Glycoprotein
- Myelin-Oligodendrocyte Glycoprotein
- Oligoclonal Bands
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Topics |
- Animals
- Disease Models, Animal
- Disease Progression
- Encephalomyelitis, Autoimmune, Experimental
(immunology, physiopathology)
- Immunization
(veterinary)
- Immunoglobulin G
(cerebrospinal fluid)
- Multiple Sclerosis
(immunology, physiopathology, veterinary)
- Myelin Basic Protein
(immunology)
- Myelin Proteins
- Myelin-Associated Glycoprotein
(immunology)
- Myelin-Oligodendrocyte Glycoprotein
- Oligoclonal Bands
(cerebrospinal fluid)
- Rats
- Severity of Illness Index
- Spinal Cord
(immunology)
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