Colorectal carcinoma metastases in liver: laser-induced interstitial thermotherapy--local tumor control rate and survival data.

Abstract

PURPOSE:

To evaluate the local tumor control and survival data for magnetic resonance (MR) imaging-guided laser-induced interstitial thermotherapy (LITT) of colorectal liver metastases.

MATERIALS AND METHODS:

MR imaging-guided LITT was performed in 603 patients (mean age, 61.2 years) with 1,801 liver metastases of colorectal cancer. Survival rates were calculated by means of the Kaplan-Meier method. Local tumor control and tumor volume were evaluated with nonenhanced and contrast material-enhanced MR imaging. Indications for the procedure were defined for patients with five or fewer metastases, none of which were larger than 5 cm in diameter. The indications included recurrent liver metastases after partial liver resection in 37.6% of study patients, metastases in both liver lobes in 32.5%, locally nonresectable lesions in 11.3%, general contraindications for surgery in 4.6%, and refusal to undergo surgical resection in 13.9%.

RESULTS:

Local recurrence rate at 6-month follow-up was 1.9% (nine of 474) for metastases up to 2 cm in diameter, 2.4% (13 of 539) for metastases 2.1-3.0 cm in diameter, 1.2% (four of 327) for metastases 3.1-4.0 cm in diameter, and 4.4% (13 of 294) for metastases larger than 4 cm in diameter. The mean survival rate for all treated patients, with calculation started on the date of diagnosis of the metastases (which were treated with LITT) was 4.4 years (95% CI: 4.0, 4.8) (1-year survival, 94%; 2-year survival, 77%; 3-year survival, 56%; 5-year survival, 37%). Median survival was 3.5 years (95% CI: 3.0, 3.9). Mean survival after the first LITT treatment was 3.8 years (95% CI: 3.4, 4.2). Median survival was 2.9 years (95% CI: 2.4, 3.3).

CONCLUSION:

MR imaging-guided LITT yields high local tumor control and survival rates in well-selected patients with limited liver metastases of colorectal carcinoma.

• Authors: Thomas J Vogl, Ralf Straub, Katrin Eichler, Oliver Söllner, Martin G Mack
• Journal: Radiology (Radiology) Vol. 230 Issue 2 Pg. 450-8 (Feb 2004) ISSN: 0033-8419 [Print] United States
• PMID: 14688400 (Publication Type: Journal Article)
• Copyright: Copyright RSNA, 2003

Topics

• Adult
• Aged
• Aged, 80 and over
• Colorectal Neoplasms (diagnosis, mortality, therapy)
• Female
• Follow-Up Studies
• Humans
• Hyperthermia, Induced (methods)
• Liver Neoplasms (diagnosis, mortality, secondary, therapy)
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (diagnosis, mortality, therapy)
• Palliative Care
• Survival Rate
• Treatment Outcome