Methylene blue: an effective treatment for contrast medium-induced anaphylaxis.

Abstract

BACKGROUND:

The purpose of this paper is to propose methylene blue as a lifesaving alternative drug for the treatment of contrast-induced anaphylaxis.

CASE REPORT:

In a cardiovascular catheterization laboratory invasive hemodynamic monitoring was used to document the lifesaving effect of IV bolus injections of 1.5-2 mg/Kg methylene blue solution to treat three patients for anaphylactic shock following radiocontrast injection during coronary angiography. Methylene blue administration was followed by prompt circulatory improvement, leading to hemodynamic stabilization and relief of other anaphylactic symptoms in each case. There were no deaths.

CONCLUSIONS:

Our findings suggest that methylene blue can be lifesaving in anaphylactic shock, notwithstanding some transitory side effects, such as cardiac rhythm disturbances and chest pain, both of which possibly originate from sudden myocardial perfusion deficits.

• Authors: Antonio M Oliveira Neto, Neison M Duarte, Walter V A Vicente, Fernanda Viaro, Paulo R B Evora
• Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 9 Issue 11 Pg. CS102-6 (Nov 2003) ISSN: 1234-1010 [Print] United States
• PMID: 14586280 (Publication Type: Case Reports, Journal Article)

Chemical References

• Contrast Media
• Enzyme Inhibitors
• Nitric Oxide
• Cyclic GMP
• Methylene Blue

Topics

• Anaphylaxis (chemically induced)
• Contrast Media (adverse effects)
• Cyclic GMP (metabolism)
• Enzyme Inhibitors (therapeutic use)
• Humans
• Methylene Blue (therapeutic use)
• Nitric Oxide (metabolism)