Immunoscintigraphy of septic loosening of knee endoprosthesis: a retrospective evaluation of the antigranulocyte antibody BW 250/183.

Abstract

Immunoscintigraphy with the use of the antigranulocyte antibody BW 250/183 is a reliable method for detecting infection, especially in septic loosening of hip prostheses, for which purpose quantitative interpretation of the time-activity course is employed. Therefore, we retrospectively studied whether similar results could be achieved in knee prostheses. We verified 28 scintigraphic examinations in 26 patients by histology. Scintigraphy was performed during an early (4-6 h post injection) and a late phase (23-25 h post injection). Infection was diagnosed when activity around the knee prosthesis increased by more than 10% compared with bone marrow. We found a sensitivity and a negative predictive value of 100%, a specificity of 80%, a positive predictive value of 81% and an accuracy of 89%. Specificity and accuracy are lower than in the evaluation of hip prostheses; however, in comparison to other scintigraphic modalities, scintigraphy with the antigranulocyte antibody BW 250/183 is superior in excluding infection and has better specificity and accuracy. Therefore, as in the case of hip prostheses, the described methodology appears to be the scintigraphic modality of choice for knee prostheses.

• Authors: Rigobert Klett, Jens Kordelle, Ulrich Stahl, Alexander Khalisi, Maximillian Puille, Dagmar Steiner, Richard Bauer
• Journal: European journal of nuclear medicine and molecular imaging (Eur J Nucl Med Mol Imaging) Vol. 30 Issue 11 Pg. 1463-6 (Nov 2003) ISSN: 1619-7070 [Print] Germany
• PMID: 14579084 (Publication Type: Comparative Study, Evaluation Study, Journal Article, Validation Study)

Chemical References

• Antibodies, Monoclonal
• BW 250 183
• Radiopharmaceuticals

Topics

• Aged
• Aged, 80 and over
• Antibodies, Monoclonal
• Female
• Granulocytes (diagnostic imaging)
• Humans
• Joint Instability (diagnostic imaging, etiology, pathology)
• Knee Joint (diagnostic imaging, pathology)
• Knee Prosthesis (adverse effects)
• Male
• Middle Aged
• Prosthesis Failure
• Prosthesis-Related Infections (diagnostic imaging, etiology, pathology)
• Radioimmunodetection (methods)
• Radiopharmaceuticals
• Reproducibility of Results
• Retrospective Studies
• Sensitivity and Specificity
• Sepsis (diagnostic imaging, etiology, pathology)