[Clinical observation of the efficacy of navelbine combined with ifosfamide and cisplatin in the treatment of advanced breast cancer].

Abstract

OBJECTIVE:

To observe the efficacy of navelbine combined with ifosfamide and cisplatin in the treatment of advanced breast cancer.

METHODS:

Forty cases of pathologically confirmed stages III-IV breast cancer were treated with combined chemotherapy including intravenously infused navelbine (25 mg/m2, days 1 and 8), ifosfamide (1.3 g/m2, days 1 to 5) and cisplatin (20 mg/m2, days 1-5), administered in cycles of 21 days. The therapeutic effect was assessed after at least two cycles were completed.

RESULTS:

Complete remission was achieved in 6 cases and partial remission in 16, with an overall responding rate of 55%. The main toxicity was bone marrow suppression manifested by grades III-IV leukopenia occurring at a rate of 40%.

CONCLUSION:

Navelbine in combination with ifosfamide and cisplatin is effective and safe in the treatment of advanced breast cancer.

• Authors: Hang Zheng, Rong-cheng Luo, Chang-xuan You
• Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA (Di Yi Jun Yi Da Xue Xue Bao) Vol. 23 Issue 10 Pg. 1088-9, 1092 (Oct 2003) ISSN: 1000-2588 [Print] China
• PMID: 14559702 (Publication Type: Journal Article)

Chemical References

• Vinblastine
• Cisplatin
• Vinorelbine
• Ifosfamide

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Breast Neoplasms (drug therapy)
• Cisplatin (administration & dosage)
• Female
• Humans
• Ifosfamide (administration & dosage)
• Middle Aged
• Vinblastine (administration & dosage, analogs & derivatives)
• Vinorelbine