In order to find a highly efficient compound against
Clonorchis infection, the
anthelmintic activity of
disophenol, Tremerad (SYD-230),
dithiazanine iodide,
dehydroemetine-late-release
tablets(RO 1-9334/20),
niridazole (
Ambilhar),
hexachlorophene (G-11), Hetol(1, 4-bis-trichloromethylbenzol) and Bilevon (
niclofolan) was tested against Clonorchis sinensis experimentally infected rabbits. All drugs showed a progressive increase in efficacy as the dose rate. They were highly efficient against
Clonorchis infection if sufficiently high, potentially toxic doses were given. The efficacy was evaluated by the number of detected worms with vital condition at autopsy after the treatment with above drugs. The high efficacy was observed at the following dose rates of each drugs, i.e.
disophenol at a single dose of 30 mg/kg, Tremerad at the daily dose of 200 mg/kg for 10 consecutive days,
dithiazanine iodide at the daily dose of 50 mg/kg for 6 consecutive days,
dehydroemetine at the daily dose of 10 mg/kg for 10 consecutive days,
hexachlorophene at the daily dose of 20 mg/kg for 10 to 15 consecutive days,
Hetol at the daily doses from 50 to 100 mg/kg for 5 to 10 consecutive days, and Bilevon at a single dose of 8 mg/kg. Moderate effectiveness was shown in
niridazole at the dose of 25 mg/kg for 10 days medication. The use of these
anthelmintics for the clinical treatment of
Clonorchis sinensis infection is discussed.