Long-term effect of low-density lipoprotein apheresis in patients with homozygous familial hypercholesterolemia.

Abstract

Patients that are homozygous for familial hypercholesterolemia (FH) exhibit severe hypercholesterolemia, cutaneous and tendon xanthomas and premature atherosclerosis beginning in childhood. They are resistant to drug therapy and low-density lipoprotein (LDL) apheresis is the practical treatment. Here we review the technique of LDL apheresis treatment, the long-term effects of LDL apheresis, the effect of apheresis on pregnancy, and the drugs that have proven beneficial in patients with homozygous FH. We also record our experiences of treating eight homozygous FH patients using the LDL apheresis treatment. Among the eight patients, one has been free from cardiovascular disease and two patients have each regressed once. In two patients, aortic valve stenosis developed and the other two patients died for acute myocardial infarction. Furthermore, two patients delivered healthy babies in spite of coronary artery disease. Thus, LDL apheresis therapy has the possibility of preventing the progression of atherosclerosis, but the prognosis assessed by long-term observation is still not satisfactory. A recent clinical trial showed some efficacy of the combination therapy of LDL apheresis and atorvastatin for reducing serum cholesterol levels in homozygous FH, suggesting that this combination therapy may be useful for prevention of atherosclerosis in patients homozygous for FH.

• Authors: Hisashi Makino, Mariko Harada-Shiba
• Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (Ther Apher Dial) Vol. 7 Issue 4 Pg. 397-401 (Aug 2003) ISSN: 1744-9979 [Print] Australia
• PMID: 12887721 (Publication Type: Comparative Study, Journal Article, Review)

Chemical References

• Lipoproteins, LDL

Topics

• Cardiovascular Diseases (prevention & control)
• Female
• Follow-Up Studies
• Homozygote
• Humans
• Hyperlipoproteinemia Type II (diagnosis, therapy)
• Lipoproteins, LDL (blood)
• Male
• Plasmapheresis (methods)
• Pregnancy
• Risk Assessment
• Severity of Illness Index
• Time Factors
• Treatment Outcome