A pediatric case of sclerodermatous chronic graft-versus-host disease.

Abstract

We report a rare case of sclerodermatous chronic graft-versus-host disease (GVHD) in a 6-year-old boy that occurred after bone marrow transplantation for his aplastic anemia. The clinical manifestation and histopathologic findings were typical of scleroderma. Although various kinds of treatment have been tried for scleroderma, no established therapy exists. Furthermore, treating this disease is even more difficult in children. In the future, clarification of the pathogenesis of chronic GVHD and establishment of therapy will be necessary.

• Authors: Kenjiro Terasaki, Takuro Kanekura, Mitsuru Setoyama, Tamotsu Kanzaki
• Journal: Pediatric dermatology (Pediatr Dermatol) 2003 Jul-Aug Vol. 20 Issue 4 Pg. 327-31 ISSN: 0736-8046 [Print] United States
• PMID: 12869155 (Publication Type: Case Reports, Journal Article)

Topics

• Anemia, Aplastic (surgery)
• Bone Marrow Transplantation (adverse effects)
• Child
• Chronic Disease
• Graft vs Host Disease (etiology, pathology, therapy)
• Humans
• Male
• Scleroderma, Diffuse (etiology, pathology, therapy)