Hypersensitivity pneumonitis induced by hexamethylene diisocyanate.

Abstract

A case of hypersensitivity pneumonitis (HP) induced by hexamethylene diisocyanate (HDI) is described. Serial determinations of the lymphocyte surface phenotypes by two-color assay revealed the following: 1) increased activated cytotoxic T lymphocytes in the bronchoalveolar lavage fluid (BALF), and 2) increased percentage and absolute number of non-major histocompatibility complex (MHC)-restricted natural killer (NK) cells in the peripheral blood (PB) during the recovery phase of the disease. These findings were considered to be related to the activity of the disease.

• Authors: Y Usui, H Aida, Y Kimula, H Miura, S Takayama, M Nakayama
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 31 Issue 7 Pg. 912-6 (Jul 1992) ISSN: 0918-2918 [Print] Japan
• PMID: 1280491 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, CD
• Antigens, Differentiation, T-Lymphocyte
• CD56 Antigen
• Cyanates
• Isocyanates
• Receptors, IgG
• 1,6-hexamethylene diisocyanate

Topics

• Alveolitis, Extrinsic Allergic (blood, chemically induced, pathology)
• Antigens, CD (analysis)
• Antigens, Differentiation, T-Lymphocyte (analysis)
• Bronchoalveolar Lavage Fluid (pathology)
• CD56 Antigen
• Cyanates (adverse effects, immunology)
• Humans
• Isocyanates
• Killer Cells, Natural (pathology)
• Lymphocyte Subsets
• Male
• Middle Aged
• Occupational Diseases (blood, chemically induced, pathology)
• Paintings
• Receptors, IgG (analysis)