Osteopontin polymorphisms and disease course in multiple sclerosis.

Abstract

Osteopontin (OPN), also known as early T-cell activating gene (Eta-1), has been recently shown to be a critical factor in the progression of experimental autoimmune encephalomyelitis, and perhaps multiple sclerosis (MS). Here we investigated whether the 327T/C, 795C/T, 1128A/G or 1284A/C single-nucleotide polymorphisms in the OPN gene were correlated with susceptibility or any of the several clinical end points in a cohort of 821 MS patients. Overall, we observed no evidence of genetic association between the OPN polymorphisms and MS. Although not reaching statistical significance, a modest trend for association with disease course was detected in patients carrying at least one wild-type 1284A allele, suggesting an effect on disease course. Patients with this genotype were less likely to have a mild disease course and were at increased risk for a secondary-progressive clinical type.

• Authors: S Caillier, L F Barcellos, S E Baranzini, A Swerdlin, R R Lincoln, L Steinman, E Martin, J L Haines, M Pericak-Vance, S L Hauser, J R Oksenberg, Multiple Sclerosis Genetics Group
• Journal: Genes and immunity (Genes Immun) Vol. 4 Issue 4 Pg. 312-5 (Jun 2003) ISSN: 1466-4879 [Print] England
• PMID: 12761568 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• SPP1 protein, human
• Sialoglycoproteins
• Osteopontin

Topics

• Adult
• Alleles
• Confidence Intervals
• Female
• Gene Frequency (genetics)
• Genotype
• Humans
• Male
• Multiple Sclerosis (genetics, physiopathology)
• Multiple Sclerosis, Chronic Progressive (genetics, physiopathology)
• Odds Ratio
• Osteopontin
• Polymorphism, Genetic (genetics)
• Sialoglycoproteins (genetics)