Distribution of prognostically unfavourable product of c-erbB-2 oncogene and EGF-R in carcinomas of the breast and uterine cervix.

Abstract

A comparative study was undertaken between cancer of the uterine cervix (n = 50) and female breast cancer (n = 50) with reference to the expression of c-erbB-2 oncoprotein (HER-2/neu) and that of epidermal growth factor receptor (EGF-R), both being highly homologous structurally. Expressions of EGF-R and c-erbB-2 oncoprotein were viewed in breast and cervical cancer tissues by immunochemical staining. Cervical cancer cases showed much higher expression of EGF-R which also revealed significant association with the expression of c-erbB-2 oncoprotein and tumour grading. Among breast cancer cases, over-expression of EGF-R correlated significantly with metastasis of lymph node; and expression of c-erbB-2 oncoprotein showed a significant relationship with histological grading of the tumour. Moreover, an association was noticed between the tumour grade and the concomitant immuno positive expression of EGF-R and c-erbB-2. Our study revealed an existence of a conflicting pattern in the expression of EGF-R and c-erbB-2 oncoprotein between carcinomas of the breast and uterine cervix.

• Authors: A Ray, S L D Naik, B K Sharma
• Journal: Indian journal of physiology and pharmacology (Indian J Physiol Pharmacol) Vol. 46 Issue 4 Pg. 423-33 (Oct 2002) ISSN: 0019-5499 [Print] India
• PMID: 12683217 (Publication Type: Comparative Study, Journal Article)

Chemical References

• ErbB Receptors
• Receptor, ErbB-2

Topics

• Adult
• Breast Neoplasms (metabolism)
• Carcinoma, Ductal, Breast (metabolism)
• Carcinoma, Squamous Cell (metabolism)
• ErbB Receptors (metabolism)
• Female
• Gene Expression Regulation, Neoplastic (physiology)
• Humans
• Middle Aged
• Receptor, ErbB-2 (genetics, metabolism)
• Uterine Neoplasms (metabolism)