Combined effect of clarithromycin and imipenem/cilastatin against urinary biofilm infection after pyeloplasty.

Abstract

The present report concerns a 38-year-old man, who had been treated with pyeloplasty and lithotomy for the improvement of urinary excretion and resolution of a kidney stone. The patient developed a biofilm infection involving Pseudomonas aeruginosa and Staphylococcus epidermidis, and had been suffering from recurrent acute pyelonephritis for one year. Combination therapy with clarithromycin (CAM) and imipenem/cilastatin (IMP/CS) consisted of administration of CAM at a dose of 400 mg/day for 1 week, followed by 500 mg/day of IMP by intravenous infusion combined with CAM (400 mg/day) for 5 days. This therapy produced an immediate antimicrobial effect and no further signs of pyuria have been seen during one year of follow-up in this patient.

• Authors: Masayuki Furuhata, Masatsugu Iwamura, Shiro Baba, Matsuhisa Inoue
• Journal: International journal of urology : official journal of the Japanese Urological Association (Int J Urol) Vol. 10 Issue 4 Pg. 228-30 (Apr 2003) ISSN: 0919-8172 [Print] Australia
• PMID: 12657103 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cilastatin
• Imipenem
• Clarithromycin

Topics

• Adult
• Biofilms (drug effects, growth & development)
• Cilastatin (therapeutic use)
• Clarithromycin (therapeutic use)
• Drug Therapy, Combination (therapeutic use)
• Humans
• Imipenem (therapeutic use)
• Kidney Calculi (complications, surgery)
• Kidney Pelvis (surgery)
• Male
• Postoperative Complications
• Pseudomonas Infections (drug therapy, microbiology)
• Pseudomonas aeruginosa (isolation & purification)
• Pyelonephritis (microbiology)
• Staphylococcal Infections (drug therapy, microbiology)
• Staphylococcus epidermidis (isolation & purification)
• Treatment Outcome
• Ureteral Obstruction (complications, surgery)