Antineoplastic agents 390. Isolation and structure of phakellistatin 12 from a Chuuk archipelago marine sponge.

Abstract

A new cancer cell growth inhibitory (P388 lymphocytic leukemia ED(50) 2.8 microg/mL) cyclodecapeptide designated phakellistatin 12 (2) has been isolated as a trace (1.7 x 10(-6)% yield) constituent of the Western Pacific Ocean (Federated States of Micronesia-Chuuk) sponge Phakellia sp. Employing principally a combination of high resolution FAB with high field (500 MHz) 1H, 13C and 2-D NMR and chiral GC analyses the structure (all S chirality) cyclo-Ile-Phe-Thr-Leu-Pro-Pro-Tyr-Ile-Pro-Pro was assigned.

• Authors: George R Pettit, Rui Tan
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 13 Issue 4 Pg. 685-8 (Feb 24 2003) ISSN: 0960-894X [Print] England
• PMID: 12639558 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Peptides, Cyclic
• phakellistatin 12

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification)
• Chromatography, Gas
• Magnetic Resonance Spectroscopy
• Molecular Structure
• Peptides, Cyclic (chemistry, isolation & purification)
• Porifera (chemistry)
• Spectrometry, Mass, Fast Atom Bombardment
• Stereoisomerism