Successful treatment of inflammatory myofibroblastic tumor with malignant transformation by surgical resection and chemotherapy.

Abstract

Inflammatory myofibroblastic tumor (IMT) is a tumor composed of myofibroblasts and a mixed inflammatory infiltrate that rarely undergoes malignant transformation. The authors present the case of a 7-year-old boy with an abdominal mass diagnosed as IMT with malignant transformation. The tumor recurred twice after attempts at resection and was initially treated with vincristine and etoposide. After a third recurrence and incomplete resection, he was treated with cisplatin, Adriamycin, and methotrexate. He is disease-free after 2 years, representing successful combined surgery and chemotherapy in the treatment of malignant IMT. The use of chemotherapy for aggressive myofibroblastic tumors is reviewed.

• Authors: Megan K Dishop, Brad W Warner, Louis P Dehner, Vesna M Kriss, Martha F Greenwood, John D Geil, Jeffrey A Moscow
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 25 Issue 2 Pg. 153-8 (Feb 2003) ISSN: 1077-4114 [Print] United States
• PMID: 12571469 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Abdominal Neoplasms (drug therapy, pathology, surgery)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cell Transformation, Neoplastic
• Child
• Humans
• Inflammation
• Male
• Neoplasm Recurrence, Local (drug therapy, surgery)
• Neoplasms, Muscle Tissue (drug therapy, pathology, surgery)
• Tomography, X-Ray Computed
• Treatment Outcome