Molecular analysis and pathology of a second pediatric HIV-associated Burkitt lymphoma.

Abstract

Diagnosis of a second HIV-associated non-Hodgkin lymphoma (HIV-NHL) is rare, but additional cases may occur as aggressive therapy for both HIV and NHL improves. An 11-year-old presented with a second primary HIV-NHL following remission for 9 years. Analysis of the tumor demonstrated presence of EBV and HIV with absence of CMV, HHV-8, and HHV-6. Although microscopic disease was present only in CSF, analysis of peripheral blood and bone marrow by PCR was positive. The patient underwent a stem cell transplant, but within 3 months, his disease recurred. Analysis for residual disease and viruses in similar cases may provide information in understanding pediatric HIV-NHL.

• Authors: Eve Cabalo, Robert Wilkinson, Nu T Lu, Sheri Shimizu, Marian Melish, Kenneth L McClain, Hal B Jenson, Bruce Shiramizu
• Journal: Pediatric pathology & molecular medicine (Pediatr Pathol Mol Med) 2002 Nov-Dec Vol. 21 Issue 6 Pg. 525-30 ISSN: 1522-7952 [Print] United States
• PMID: 12537769 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anti-HIV Agents

Topics

• Anti-HIV Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Burkitt Lymphoma (genetics, pathology, virology)
• Child
• HIV (metabolism)
• HIV Infections (complications)
• Herpesvirus 4, Human (metabolism)
• Humans
• Lymphatic Metastasis (pathology)
• Lymphoma, AIDS-Related (pathology)
• Male
• Neoplasms, Second Primary (genetics, pathology, virology)
• Polymerase Chain Reaction
• Tomography, X-Ray Computed