Abstract | BACKGROUND: OBJECTIVES: To determine the safety and effectiveness of N-9 in preventing vaginal acquisition of HIV infection by women from men. SEARCH STRATEGY: Extensive searches of electronic databases, conference abstracts, reference lists of relevant studies and contact with experts and funders. SELECTION CRITERIA: Randomised controlled trials meeting pre-determined quality criteria with HIV infection as the outcome. DATA COLLECTION AND ANALYSIS: Data were extracted by one reviewer and checked by the another. Any discrepancies were adjudicated by a third reviewer. MAIN RESULTS: Five trials were included in the review and four contributed to a meta-analysis. Overall, the risk of HIV infection was not statistically significantly different among women receiving N-9 (relative risk [RR] 1.12, 95% CI 0.88-1.42; p=0.4). The risk of genital lesions was statistically significantly greater among women receiving N-9 (RR 1.18, 95%CI 1.02-1.36; p=0.02). REVIEWER'S CONCLUSIONS: There is no evidence that nonoxynol-9 protects against vaginal acquisition of HIV infection by women from men. There is evidence that it may do harm by increasing the frequency of genital lesions.
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Authors | D Wilkinson, G Ramjee, M Tholandi, G Rutherford |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 4
Pg. CD003936
( 2002)
ISSN: 1469-493X [Electronic] England |
PMID | 12519622
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Spermatocidal Agents
- Nonoxynol
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Topics |
- Coitus
- Female
- HIV Infections
(prevention & control, transmission)
- Humans
- Male
- Nonoxynol
(therapeutic use)
- Randomized Controlled Trials as Topic
- Spermatocidal Agents
(therapeutic use)
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