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Interleukin-11 administration normalizes the platelet count in a hypersplenic cirrhotic patient.

Abstract
We report the successful administration of interleukin-11 (IL-11 or oprelvekin), a promoter of megakaryocyte maturation, to a 54-year-old male Jehovah's Witness with hepatic cirrhosis and hypersplenic thrombocytopenia requiring surgery for symptomatic interstitial cystitis. This observation suggests that oprelvekin might be crucial in the acute management of certain types of hypersplenic thrombocytopenias.
AuthorsC Ustun, P M Dainer, G B Faguet
JournalAnnals of hematology (Ann Hematol) Vol. 81 Issue 10 Pg. 609-10 (Oct 2002) ISSN: 0939-5555 [Print] Germany
PMID12424546 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Interleukin-11
Topics
  • Cystitis, Interstitial
  • Humans
  • Hypersplenism (drug therapy)
  • Interleukin-11 (administration & dosage)
  • Jehovah's Witnesses
  • Liver Cirrhosis (drug therapy)
  • Male
  • Middle Aged
  • Platelet Count
  • Thrombocytopenia (drug therapy)
  • Treatment Refusal

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