Abstract | BACKGROUND: METHODS: From 1981 to 1995, 68 stage I-II cervical carcinoma patients without nodal disease who received adjuvant pelvic radiotherapy were entered into the present analysis. Criteria for postoperative radiotherapy were (1) deep stromal invasion (> or = 1/2; n = 63), (2) positive parametrial invasion (n = 38) and (3) close or positive surgical margin (n = 21). The median patient age was 54.0 years (range, 29-69 years). The median dose of 45.3 Gy (range, 43.4-56.4 Gy) was delivered over the whole pelvis median 21.0 days (range 12-68 days) after surgery. RESULTS: The 5/10-year overall survival, disease-free survival, pelvic control and distant metastasis-free survival rates were 89.7/85.7, 85.3/83.2, 95.5/95.5 and 90.7/90.7%, respectively. Histology of adenocarcinoma (n = 4), large tumor size and prolonged period between operation and radiotherapy were significantly adverse prognostic factors of overall and disease-free survival by univariate analysis. The risk score referred from the GOG report correlated well with disease-free survival (P = 0.018), but showed only a tendency for overall survival as a prognostic factor (P = 0.07). Overall treatment time proved to be a significant variable for overall survival (P = 0.02), but not for disease-free survival (P = 0.056). Both risk score and overall treatment time proved to be significant prognostic factors in the multivariate model. Major adverse effects occurred in three patients (4.4%) without mortality. CONCLUSIONS: In this analysis, clinical outcome from adjuvant postoperative radiotherapy was thought to be feasible with both satisfactory pelvic control and acceptable lower toxicity.
|
Authors | Takeshi Kodaira, Nobukazu Fuwa, Toru Nakanishi, Kazuo Kuzuya, Masahiro Sasaoka, Kazuhisa Furutani, Minoru Kamata |
Journal | Japanese journal of clinical oncology
(Jpn J Clin Oncol)
Vol. 32
Issue 7
Pg. 255-61
(Jul 2002)
ISSN: 0368-2811 [Print] England |
PMID | 12324576
(Publication Type: Evaluation Study, Journal Article)
|
Topics |
- Adult
- Aged
- Female
- Humans
- Lymphatic Metastasis
- Middle Aged
- Postoperative Period
- Radiotherapy, Adjuvant
- Retrospective Studies
- Treatment Outcome
- Uterine Cervical Neoplasms
(pathology, radiotherapy, surgery)
|