Putative drug-related pemphigus foliaceus in four dogs.

Abstract

Four dogs developed cutaneous lesions following the administration of various antibiotics. Histopathology of the lesions was compatible with pemphigus foliaceus, although apoptotic cells suggestive of erythema multiforme were seen in two cases. In two dogs the lesions resolved after 7.5-8.5 months of immune-suppressive treatment. No recurrence was seen during the follow-up period (3 and 4.5 years). The lesions in the other two dogs resolved within 3 weeks to 3 months following discontinuation of the antibiotic. No recurrence of clinical signs occurred during the follow-up period (1 and 4 years, respectively).

• Authors: Stephen D White, Didier N Carlotti, Didier Pin, Terri Bonenberger, Peter J Ihrke, Eric Monet, Koji Nishifuji, Toshiroh Iwasaki, Mark G Papich
• Journal: Veterinary dermatology (Vet Dermatol) Vol. 13 Issue 4 Pg. 195-202 (Aug 2002) ISSN: 0959-4493 [Print] England
• PMID: 12174181 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Immunosuppressive Agents

Topics

• Animals
• Anti-Bacterial Agents (adverse effects)
• Diagnosis, Differential
• Dog Diseases (chemically induced, diagnosis, drug therapy, pathology)
• Dogs
• Drug Eruptions (diagnosis, veterinary)
• Female
• Immunosuppressive Agents (therapeutic use)
• Male
• Pemphigus (diagnosis, veterinary)