Significant growth inhibition of human lung cancer cells both in vitro and in vivo by the combined use of a selective cyclooxygenase 2 inhibitor, JTE-522, and conventional anticancer agents.

Abstract	This study reports that a selective COX-2 inhibitor JTE-522inhibits both in vitro and in vivo growth of human lung cancer cells as a single agent. Furthermore, the adjunct use of JTE-522 is shown to significantly enhance treatment efficacy of conventional anticancer drugs not only in vitro but also in vivo without causing any noticeable side effects. Indeed, IC(50)s of various anticancer agents in vitro were reduced by up to 70%, whereas the combination therapy of JTE-522 with docetaxel and vinorelbine inhibited tumor growth in vivo by 65 and 55%, respectively. Taken together, these findings suggest that the use of a selective COX-2 inhibitor in the treatment of lung cancer may be promising, especially because of its enhancement of the treatment efficacy of conventional anticancer agents without compromising quality of life.
Authors	Toyoaki Hida, Ken-Ichi Kozaki, Hidemi Ito, Osamu Miyaishi, Yoshio Tatematsu, Takeshi Suzuki, Keitaro Matsuo, Takahiko Sugiura, Makoto Ogawa, Toshitada Takahashi, Takashi Takahashi
Journal	Clinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res) Vol. 8 Issue 7 Pg. 2443-7 (Jul 2002) ISSN: 1078-0432 [Print] United States
PMID	12114451 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide Anthracyclines Antibiotics, Antineoplastic Benzenesulfonates Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Isoenzymes Membrane Proteins Oxazoles Taxoids Docetaxel Vinblastine amrubicin Cyclooxygenase 2 PTGS2 protein, human Prostaglandin-Endoperoxide Synthases Paclitaxel Vinorelbine
Topics	Adenocarcinoma (drug therapy, metabolism, pathology) Animals Anthracyclines Antibiotics, Antineoplastic (pharmacology) Antineoplastic Combined Chemotherapy Protocols (therapeutic use) Benzenesulfonates (therapeutic use) Cell Division (drug effects) Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors (therapeutic use) Docetaxel Drug Resistance, Neoplasm Female Humans In Vitro Techniques Isoenzymes (antagonists & inhibitors) Lung Neoplasms (drug therapy, metabolism, pathology) Membrane Proteins Mice Mice, Nude Neoplasm Transplantation Oxazoles (therapeutic use) Paclitaxel (administration & dosage, analogs & derivatives) Prostaglandin-Endoperoxide Synthases Taxoids Tumor Cells, Cultured (drug effects) Vinblastine (administration & dosage, analogs & derivatives) Vinorelbine

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