[Glutoxim in the complex treatment of tuberculosis].

Abstract

Results of Glutoxim investigation are presented. Glutoxim is the the drug of the new class--thiopoietins. It is considered to be immunorehabilitator as it modulates intracellular process of thiols metabolism, initiates cytokins system, activates phagocytosis etc. Results of the glutoxim administration at the 42 patients with tuberculosis using traditional treatment regimes are presented. Results of the randomized study at the patients with severe disseminated drug-sensitive and drug-resistant pulmonary tuberculosis demonstrated high efficacy of the glutoxim and its good tolerability. Glutoxim administration allowed to shorten the period of tuberculosis intoxication signs disappearance, to shorten the period of sputum negativation and shortened the period of pulmonary inflammation reverse process. Glutoxim application was specially favorable at the patients with severe tuberculosis complicated by viral or medicamental hepatitis.

• Authors: G B Sokolova, M V Sinitsyn, L A Kozhemiakin, M I Perel'man
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 47 Issue 2 Pg. 20-3 ( 2002) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Glutoksim v kompleksnoĭ terapii tuberkuleza.
• PMID: 12087719 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Adjuvants, Immunologic
• Antitubercular Agents
• Oligopeptides
• glutoxim

Topics

• Adjuvants, Immunologic (adverse effects, therapeutic use)
• Adolescent
• Adult
• Aged
• Antitubercular Agents (adverse effects, therapeutic use)
• Chemical and Drug Induced Liver Injury (complications)
• Drug Resistance, Bacterial
• Hepatitis, Viral, Human (complications)
• Humans
• Middle Aged
• Oligopeptides (adverse effects, therapeutic use)
• Tuberculosis, Pulmonary (complications, drug therapy)