Abstract |
We typed 241 members of 62 sarcoidosis families with 136 affected siblings for three single nucleotide polymorphisms of the interleukin-4 receptor alpha-chain gene (IL4R). Allele frequencies in patients were compared to those of healthy unrelated control individuals. The segregation of the three-point IL4R haplotypes completed by two flanking highly polymorphic microsatellite polymorphisms revealed no evidence for linkage of the IL4R gene locus with sarcoidosis.
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Authors | A Bohnert, M Schürmann, A Hartung, H Hackstein, J Müller-Quernheim, G Bein |
Journal | European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics
(Eur J Immunogenet)
Vol. 29
Issue 3
Pg. 269-72
(Jun 2002)
ISSN: 0960-7420 [Print] England |
PMID | 12047365
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Chromosome Mapping
- Chromosomes, Human, Pair 16
- Genetic Linkage
- Germany
- Humans
- Receptors, Interleukin-4
(genetics)
- Sarcoidosis
(genetics)
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