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No linkage of the interleukin-4 receptor locus on chromosome 16p11.2-12.1 with sarcoidosis in German multiplex families.

Abstract
We typed 241 members of 62 sarcoidosis families with 136 affected siblings for three single nucleotide polymorphisms of the interleukin-4 receptor alpha-chain gene (IL4R). Allele frequencies in patients were compared to those of healthy unrelated control individuals. The segregation of the three-point IL4R haplotypes completed by two flanking highly polymorphic microsatellite polymorphisms revealed no evidence for linkage of the IL4R gene locus with sarcoidosis.
AuthorsA Bohnert, M Schürmann, A Hartung, H Hackstein, J Müller-Quernheim, G Bein
JournalEuropean journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics (Eur J Immunogenet) Vol. 29 Issue 3 Pg. 269-72 (Jun 2002) ISSN: 0960-7420 [Print] England
PMID12047365 (Publication Type: Journal Article)
Chemical References
  • Receptors, Interleukin-4
Topics
  • Chromosome Mapping
  • Chromosomes, Human, Pair 16
  • Genetic Linkage
  • Germany
  • Humans
  • Receptors, Interleukin-4 (genetics)
  • Sarcoidosis (genetics)

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