Lack of MHC expression and retention of ultrastructural characteristics by xenograft transmissible venereal tumor cells in SCID mice.

Abstract

Canine transmissible venereal tumor (CTVT) is primarily a tumor of adult dogs with a high incidence of spontaneous regression. We recently reported a xenograft model of CTVT (XTVT) in NOD/SCID mice. XTVT cells retain cytological and histological features of CTVT as well as characteristic rearranged LINE/c-MYC junction [Am. J. Vet. Res. 62 (2001) 907]. In this paper, we demonstrate that XTVT cells maintain ultrastructural characteristics of CTVT and do not express MHC classes I and II molecules.

• Authors: A Harmelin, J H Pinthus, D Friedmann-Morvinski, K Kaufman, O Brenner
• Journal: Veterinary immunology and immunopathology (Vet Immunol Immunopathol) Vol. 86 Issue 3-4 Pg. 245-9 (Jul 2002) ISSN: 0165-2427 [Print] Netherlands
• PMID: 12007890 (Publication Type: Journal Article)

Topics

• Animals
• Disease Models, Animal
• Dog Diseases (immunology, pathology)
• Dogs
• Flow Cytometry
• Gene Expression Regulation, Neoplastic (immunology)
• Genes, MHC Class I (immunology)
• Genes, MHC Class II (immunology)
• Major Histocompatibility Complex (immunology, physiology)
• Mice
• Mice, Inbred NOD
• Mice, SCID
• Microscopy, Electron
• Neoplasm Transplantation
• Specific Pathogen-Free Organisms
• Transplantation, Heterologous
• Venereal Tumors, Veterinary (immunology, pathology, ultrastructure)