The characteristics of side-effects of bromperidol in schizophrenic patients.

Abstract

The characteristics of the side-effects of bromperidol was investigated in 33 acutely exacerbated schizophrenic patients. The most frequently observed side-effects were extrapyramidal symptoms. Acute dystonia developed in 10 of 33 patients, and the mean age was significantly lower (P < 0.05) in patients with dystonia (27.3 +/- 6.2 years) than that in patients without dystonia (41.5 +/- 12.9 years). Plasma drug concentrations were not associated with side-effects. These findings suggest that acute dystonia is affected by age factor, and that daily dosage or monitoring of drug concentration is unlikely to be a useful marker for the prediction of side-effects during bromperidol treatment.

• Authors: Norio Yasui-Furukori, Tsuyoshi Kondo, Masayuki Ishida, Osamu Tanaka, Kazuo Mihara, Sunao Kaneko, Koichi Otani
• Journal: Psychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 56 Issue 1 Pg. 103-6 (Feb 2002) ISSN: 1323-1316 [Print] Australia
• PMID: 11929578 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antipsychotic Agents
• Haloperidol
• bromperidol

Topics

• Adult
• Antipsychotic Agents (adverse effects, blood, therapeutic use)
• Dystonia (chemically induced)
• Female
• Haloperidol (adverse effects, analogs & derivatives, blood, therapeutic use)
• Humans
• Hypokinesia (chemically induced)
• Male
• Schizophrenia (blood, drug therapy)
• Schizophrenic Psychology
• Tremor (chemically induced)