[Keratinocyte immunophenotypes in patients with psoriatic arthritis and their changes after treatment with deresinated naphthalan].

Abstract

The study of phenotyping features, membrane markers of epidermic keratinocytes, their production of adhesive molecules has established structural basis of favourable effect of deresinated naphthalan on the skin and articular syndromes in patients with psoriatic adtheritis. The immunohistochemical examination of the skin biopsies using monoclonal antibodies in the test of indirect immunofluorescence has found that deresinated naphthalan in patients suppresses immunoinflammatory reactions in the skin. Monitoring of expression of molecules HLA--on keratinocytes may be helpful for prediction of the skin and joint manifestation.

• Authors: N G Badalov, N N Tupitsyn, V D Grigor'eva
• Journal: Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury (Vopr Kurortol Fizioter Lech Fiz Kult) 2001 Nov-Dec Issue 6 Pg. 32-4 ISSN: 0042-8787 [Print] Russia (Federation)
• Vernacular Title: Immunofenotipicheskie osobennosti keratinotsitov u bol'nykh psoriaticheskim artritom i ikh izmenenie pod vliianiem obessmolennogo naftalana.
• PMID: 11868533 (Publication Type: English Abstract, Journal Article)

Chemical References

• HLA-DR Antigens
• Naphthalenes
• decalin

Topics

• Administration, Topical
• Arthritis, Psoriatic (immunology, therapy)
• Female
• HLA-DR Antigens (immunology)
• Hot Temperature
• Humans
• Immunophenotyping
• Keratinocytes (immunology)
• Male
• Naphthalenes (administration & dosage)