Liposomal amphotericin B and granulocyte colony-stimulating factor therapy in a murine model of invasive infection by Scedosporium prolificans.

Abstract	We established a reproducible lethal disseminated infection by the opportunistic fungus Scedosporium prolificans in an immunosuppressed murine model. We compared the effectiveness of the combined administration of liposomal amphotericin B (LAMB) and granulocyte colony-stimulating factor (G-CSF) with that of either agent alone and with that of amphotericin B deoxycholate (AMB). LAMB + G-CSF and LAMB treatments improved survival significantly with respect to the untreated control. The mean survival times of these three groups were 13.2, 9.1 and 7.9 days, respectively. Culture results in terms of colony counts for samples of deep organs were lower in mice treated with the combined therapy, although differences were not significant. Combined LAMB + G-CSF therapy could be a promising approach for the treatment of disseminated infections of S. prolificans, although further studies are required to determine the most appropriate doses.
Authors	Montserrat Ortoneda, Javier Capilla, Isabel Pujol, F Javier Pastor, Emilio Mayayo, Joan Fernández-Ballart, Josep Guarro
Journal	The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 49 Issue 3 Pg. 525-9 (Mar 2002) ISSN: 0305-7453 [Print] England
PMID	11864953 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antifungal Agents Liposomes Recombinant Proteins Granulocyte Colony-Stimulating Factor Amphotericin B
Topics	Amphotericin B (therapeutic use) Animals Antifungal Agents (therapeutic use) Colony Count, Microbial Disease Models, Animal Drug Therapy, Combination Granulocyte Colony-Stimulating Factor (therapeutic use) Humans Immunosuppression Therapy Liposomes Male Mice Mice, Inbred Strains Mycoses (drug therapy, mortality) Opportunistic Infections (drug therapy, mortality) Recombinant Proteins Scedosporium (drug effects, isolation & purification) Survival Rate

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