[Rhabdomyolysis and anuric kidney failure induced by the treatment with a gemfibrozil-cerivastatin combination].

Abstract

A 67-year-old man treated with gemfibrozil for a year development rhabdomyolysis and anuric renal failure after addition of cerivastatin. The clinical features and serological studies ruled out other causes of rhabdomyolysis. Drugs were stopped and hemodialysis was carried on for 14 days until diuresis occurred. The renal function improved steadily to a serum creatinine of 1.2 mg/dl two months later. On the basis of its pharmacokinetic profile cerivastatin appears to have less interactions than other statins. There are only two reports of rhabdomyolysis and acute renal failure due to fibrates and cerivastatin combination. This patient shows the potential risk of a fibrates-cerivastatin combination. When this association is required it is necessary to avoid other nephrotoxic and myopathic factors and to monitor CK levels closely.

• Authors: A E Sirvent, J B Cabezuelo, R Enríquez, F Amorós, C González, A Reyes
• Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia (Nefrologia) 2001 Sep-Oct Vol. 21 Issue 5 Pg. 497-500 ISSN: 0211-6995 [Print] Spain
• Vernacular Title: Rabdomiólisis y fracaso renal anúrico inducidos por el tratamiento combinado de gemfibrozil y cerivastatina.
• PMID: 11795020 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Hypolipidemic Agents
• Pyridines
• cerivastatin
• Gemfibrozil

Topics

• Acute Kidney Injury (chemically induced)
• Aged
• Anuria (chemically induced)
• Drug Therapy, Combination
• Gemfibrozil (adverse effects)
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects)
• Hypolipidemic Agents (adverse effects)
• Male
• Pyridines (adverse effects)
• Rhabdomyolysis (chemically induced)