[Study on human leucocyte antigen-DQ region gene polymorphism in cases of habitual abortion with anticardiolipin antibody].

Abstract

OBJECTIVE:

To investigate the relationship between human leucocyte antigen(HLA)-DQ region gene polymorphism and habitual abortion with anticardiolipin antibody(ACL).

METHODS:

Polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) was used to type HLA-DQA1 and HLA-DQB1 alleles in 30 cases of habitual abortion with anticardiolipin antibody and 90 women with normal pregnancy history.

RESULTS:

The frequency of DQB1 * 0303 was found to be significantly higher in ACL(+) habitual abortion group (33.3%) than those in normal control group (P < 0.05). Whereas, there was no significant difference found not only in frequency of other DQB1 alleles, but also in frequency of DQA1 alleles and DQA1-DQB1 haplotypes between two groups.

CONCLUSION:

The results show an association between ACL(+) habitual abortion and HLA-DQB1 * 0303, which suggest DQB1 * 0303 may be susceptible gene to ACL(+) habitual abortion.

• Authors: Q Lin, P Lu, X Wang
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 35 Issue 4 Pg. 208-11 (Apr 2000) ISSN: 0529-567X [Print] China
• PMID: 11776160 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Anticardiolipin
• HLA-DQ Antigens
• HLA-DQ alpha-Chains
• HLA-DQ beta-Chains
• HLA-DQA1 antigen
• HLA-DQB1 antigen

Topics

• Abortion, Habitual (etiology, genetics, immunology)
• Adult
• Antibodies, Anticardiolipin (analysis)
• Female
• HLA-DQ Antigens (genetics)
• HLA-DQ alpha-Chains
• HLA-DQ beta-Chains
• Humans
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• Pregnancy