Sulfasalazine-induced extrinsic allergic alveolitis in a patient with psoriatic arthritis.

Abstract

We report the first case of a well defined extrinsic allergic alveolitis as a complication of sulfasalazine therapy in a patient treated for psoriatic arthritis. CT of the chest showed small nodular densities over both lungs, BAL demonstrated a highly active lymphocytic alveolitis and transbronchial biopsies revealed lymphoplasmocytic interstitial infiltration. Sulfasalazine as causative agent was proven by an inadvertent rechallenge three years later and a positive lymphocyte transformation test. sulfasalazine; psoriatic arthritis; extrinsic allergic alveolitis

• Authors: M Woltsche, I Woltsche-Kahr, G M Roeger, W Aberer, H Popper
• Journal: European journal of medical research (Eur J Med Res) Vol. 6 Issue 11 Pg. 495-7 (Nov 20 2001) ISSN: 0949-2321 [Print] England
• PMID: 11726310 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antirheumatic Agents
• Sulfasalazine

Topics

• Aged
• Alveolitis, Extrinsic Allergic (chemically induced, diagnostic imaging, immunology)
• Antirheumatic Agents (adverse effects)
• Arthritis, Psoriatic (drug therapy)
• Humans
• Lymphocyte Activation
• Male
• Sulfasalazine (adverse effects)
• Tomography, X-Ray Computed