Dose-finding phase I study of simultaneous weekly infusion with doxorubicin and docetaxel in patients with advanced breast cancer.

Abstract

BACKGROUND:

Combination therapy with doxorubicin (DOX) and docetaxel (DOC), given 3 weeks apart, is one of the standard regimens used for treating metastatic breast cancer, but it frequently generates febrile neutropenia. To find a safer regimen with less myelotoxicity and the appropriate dose intensity, we conducted a phase I study of simultaneous weekly infusion with DOX and DOC.

METHODS:

Twenty-five patients with advanced breast cancer were treated with an intravenous push-injection of DOX that was immediately followed by a 1-h infusion of DOC. This was repeated every week for at least 6 weeks. The premedication employed was three 4-mg doses of dexamethasone every week. Patients were divided into four groups for which the doses of DOX and DOC were escalated in 5-mg/m2 increments.

RESULTS:

In the 18 patients who were treated with DOX 15 or 20 mg/m2 and DOC 25 mg/m2, or lower, the regimen was found to be tolerable, without febrile episodes. The regimen with 20 mg/m2 of DOX and 30 mg/m2 of DOC was the maximum tolerated dose. Other indications of grade 3 toxicity included asthenia in 4% of patients, anorexia in 8%, and vomiting in 8%. Of the 25 patients, 14 had a partial response. The overall response rate was 56% (95% confidence interval [CI], 35% to 77%). The recommended dose for further trial was 20 mg/m2 of DOX and 25 mg/m2 of DOC.

CONCLUSION:

Simultaneous weekly infusion with DOX and DOC was feasible, with modest neutropenia and preserved dose intensity. This regimen may be helpful in the management of patients with advanced breast cancer.

• Authors: Y Ito, K Aiba, N Horikoshi, T Saotome, T Irie, K Sugiyama, M Nakane, D Hashimoto, N Yoshida, N Mizunuma, S Takahashi, Y Tanigawara
• Journal: International journal of clinical oncology (Int J Clin Oncol) Vol. 6 Issue 5 Pg. 242-7 (Oct 2001) ISSN: 1341-9625 [Print] Japan
• PMID: 11723746 (Publication Type: Clinical Trial, Clinical Trial, Phase I, Journal Article)

Chemical References

• Taxoids
• Docetaxel
• Doxorubicin
• Paclitaxel

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects)
• Breast Neoplasms (drug therapy)
• Docetaxel
• Doxorubicin (administration & dosage, adverse effects)
• Drug Administration Schedule
• Female
• Humans
• Middle Aged
• Paclitaxel (administration & dosage, adverse effects, analogs & derivatives)
• Taxoids