Periodontal changes in liver cirrhosis and post-transplantation patients. I: clinical findings.

Abstract

BACKGROUND:

Cyclosporin A (CsA) is widely used to prevent liver transplantation failure. CsA-induced gingival overgrowth is a common side effect. However, the effect of cirrhotic liver disease, liver transplantation, and immunosuppressive therapy on the periodontium is yet unclear. The aim of the present cross-sectional study was to examine the effect of liver cirrhosis, transplantation, and immunosuppressive therapy on the periodontium.

METHODS:

The experimental group (LC) consisted of 13 liver cirrhosis patients. A second experimental group (PT) included 24 patients, post-liver transplantation, receiving immunosuppressive therapy. Seventeen healthy subjects formed a control group. The Ramfjord index teeth were recorded for plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and gingival overgrowth (GO).

RESULTS:

Mean PI and mean GI for the LC, PT, and C groups were not statistically different (P >0.05). Mean PD for the LC (3.32+/-0.24 mm) and PT group (3.41+/-0.13 mm) was significantly higher (P = 0.0001, ANOVA) compared to the C group (2.45+/-0.16 mm). Likewise, CAL for the LC (4.89+/-0.47 mm) and PT group (4.68+/-0.47 mm) was significantly higher (P = 0.001, ANOVA) than the C group (2.78+/-0.23 mm). Patients in the PT group exhibited the greatest mean GO scores (0.88+/-0.09) compared to the LC group (0.37+/-0.07) and the C group (0.09+/-0.02). All 3 groups were significantly different from each other (P = 0.0001) despite great variability within the groups. GO in the CsA-treated patients (1.1+/-0.09) was significantly higher (P = 0.0001) than in those treated with tacrolimus (0.57+/-0.1).

CONCLUSIONS:

Liver cirrhosis patients demonstrated greater pocketing and attachment loss compared to healthy matched controls. These same differences were observed in patients post-transplantation. Gingival overgrowth occurred as a result of the immunosuppressive therapy with CsA, while to a lesser degree with tacrolimus. Replacement of CsA by tacrolimus in patients manifesting gingival overgrowth might be recommended whenever possible to overcome this problem.

• Authors: O Oettinger-Barak, S Barak, E E Machtei, L Ardekian, Y Baruch, M Peled
• Journal: Journal of periodontology (J Periodontol) Vol. 72 Issue 9 Pg. 1236-40 (Sep 2001) ISSN: 0022-3492 [Print] United States
• PMID: 11577956 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Immunosuppressive Agents
• Cyclosporine
• Tacrolimus

Topics

• Analysis of Variance
• Cyclosporine (adverse effects)
• Female
• Gingival Hyperplasia (etiology)
• Humans
• Immunosuppressive Agents (adverse effects)
• Liver Cirrhosis (complications)
• Liver Transplantation (adverse effects)
• Male
• Middle Aged
• Statistics, Nonparametric
• Tacrolimus (adverse effects)