Prognostic factors in hepatic metastases of colorectal carcinoma: immunohistochemical analysis of tumor biological factors.
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| Abstract |
The present study was designed to provide a systemic analysis of prognosis in 62 patients who underwent hepatic resection for colorectal liver metastasis. The analyzed factors included microvessel counts stained by CD34 and expression of two adhesion molecules, E-cadherin and CD44 variant exon 6-(v6) in these tumors. No significant factors related to recurrence were identified and only negative expression of CD44v6 tended to correlate with recurrence (P = 0.075). A short disease-free period to recurrence was noted in patients with high CEA levels (>10 ng/ml) and H2/3 classification. A short surgical margin, H2/3 classification, high microvessel counts (>60/field, x200), and negative expression of CD44v6 and E-cadherin tended to be associated with poor prognosis. A high microvessel count was the most significant prognostic factor by multivariate Cox proportional hazards regression model. Hepatic resection without tumor exposure and a careful follow-up in cases identified with poor prognostic factors are necessary.
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| Authors | A Nanashima, H Yamaguchi, T Sawai, E Yamaguchi, H Kidogawa, S Matsuo, T Yasutake, T Tsuji, M Jibiki, T Nakagoe, H Ayabe |
| Journal | Digestive diseases and sciences (Dig Dis Sci) Vol. 46 Issue 8 Pg. 1623-8 (Aug 2001) ISSN: 0163-2116 [Print] United States |
| PMID | 11508659 (Publication Type: Journal Article) |
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