BOLD MRI of human tumor oxygenation during carbogen breathing.
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| Abstract |
An MRI method is described for demonstrating improved oxygenation of human tumors and normal tissues during carbogen inhalation (95% O2, 5% CO2). T2*-weighted gradient-echo imaging was performed before, during, and after carbogen breathing in 47 tumor patients and 13 male volunteers. Analysis of artifacts and signal intensity was performed. Thirty-six successful tumor examinations were obtained. Twenty showed significant whole-tumor signal increases (mean 21.0%, range 6.5-82.4%), and one decreased (-26.5 +/- 8.0%). Patterns of signal change were heterogeneous in responding tumors. Five of 13 normal prostate glands (four volunteers and nine patients with nonprostatic tumors) showed significant enhancement (mean 11.4%, range 8.4-14.0%). An increase in brain signal was seen in 11 of 13 assessable patients (mean 8.0 +/- 3.7%, range 5.0-11.7%). T2*-weighted tumor MRI during carbogen breathing is possible in humans. High failure rates occurred due to respiratory distress. Significant enhancement was seen in 56%, suggesting improved tissue oxygenation and blood flow, which could identify these patients as more likely to benefit from carbogen radiosensitization.
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| Authors | N J Taylor, H Baddeley, K A Goodchild, M E Powell, M Thoumine, L A Culver, J J Stirling, M I Saunders, P J Hoskin, H Phillips, A R Padhani, J R Griffiths |
| Journal | Journal of magnetic resonance imaging : JMRI (J Magn Reson Imaging) Vol. 14 Issue 2 Pg. 156-63 (Aug 2001) ISSN: 1053-1807 [Print] United States |
| PMID | 11477674 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright 2001 Wiley-Liss, Inc. |
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