Severe thrombotic complications associated with activated protein C resistance acquired by orthotopic liver transplantation.

Abstract

We report a patient who developed recurrent hepatic artery thrombosis and deep venous thrombosis following orthotopic liver transplantation. Investigations revealed the presence of activated protein C (APC) resistance due to a mutation in the factor V gene in the transplanted liver. The patient's own peripheral blood cells did not carry the mutation. Although part of factor V is located in the platelets and may be endogenously synthesized by megakaryocytes, this case demonstrates the major clinical importance of hepatic-derived factor V. It may be reasonable to screen liver donors with a history of a thrombotic event for APC, and to consider anticoagulation in the recipients of livers positive for this defect.

• Authors: S Gillis, A Lebenthal, G Pogrebijsky, Y Levy, A Eldor, A Eid
• Journal: Haemostasis (Haemostasis) 2000 Nov-Dec Vol. 30 Issue 6 Pg. 316-20 ISSN: 0301-0147 [Print] Switzerland
• PMID: 11357000 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2001 S. Karger AG, Basel

Chemical References

• Factor V

Topics

• Activated Protein C Resistance (complications, etiology)
• Adult
• Arterial Occlusive Diseases (etiology)
• DNA Mutational Analysis
• Factor V (genetics)
• Hepatic Artery (pathology)
• Humans
• Liver Transplantation (adverse effects)
• Male
• Mutation
• Thrombosis (complications, etiology)
• Venous Thrombosis (etiology)