Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women.

Abstract

Little is known about the epidemiology of human herpesvirus 8 (HHV-8) infections among women. A cross-sectional study was conducted of HHV-8 infection among human immunodeficiency virus (HIV)-infected and high-risk HIV-uninfected women. Serological tests with noninduced (latent) and induced (lytic) HHV-8 antigens were used to detect infection among 2483 participants of a multisite cohort. Reactivity to latent antigen was present in 4.1% and to induced antigens in 12.0% of women. Seven of 8 women who reported Kaposi's sarcoma had HHV-8 antibodies. Among HIV-positive women, HHV-8 infection was associated with use of crack, cocaine, or heroin (76% vs. 65%; P<.001), past syphilis (29% vs. 20%; P<.001), an injection drug-using male sex partner (61% vs. 53%; P=.014), black race (P=.010), and enrollment site (P=.015). In multivariate analysis, HIV infection, older age, past syphilis, black race, and enrollment site were independently associated with HHV-8 infection. In this cohort of North American women, HHV-8 infection was associated with HIV infection, drug use, and risky sexual behavior.

• Authors: R M Greenblatt, L P Jacobson, A M Levine, S Melnick, K Anastos, M Cohen, J DeHovitz, M A Young, D Burns, P Miotti, D M Koelle
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 183 Issue 7 Pg. 1130-4 (Apr 01 2001) ISSN: 0022-1899 [Print] United States
• PMID: 11237842 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Viral
• Crack Cocaine
• Heroin
• Cocaine

Topics

• Adult
• Antibodies, Viral (blood)
• California (epidemiology)
• Cocaine
• Cohort Studies
• Crack Cocaine
• Cross-Sectional Studies
• District of Columbia (epidemiology)
• Female
• HIV Infections (complications)
• HIV Seronegativity
• HIV Seropositivity (complications)
• Heroin
• Herpesviridae Infections (complications, epidemiology)
• Herpesvirus 8, Human (immunology)
• Humans
• New York (epidemiology)
• Prevalence
• Risk Factors
• Sarcoma, Kaposi (complications, epidemiology)
• Seroepidemiologic Studies
• Sex Factors
• Substance Abuse, Intravenous
• Syphilis (complications)