Dopamine-B-hydroxylase and catecholamines in an olfactory esthesioneuroma.

Abstract

In a case of olfactory esthesioneuroma, of which an unfixed specimen and blood sample were available, we demonstrated immunohistochemically and biochemically the presence of dopamine-B-hydroxylase and catecholamines in low concentration. This result indicates that this nasal tumor is probably of sympathetic origin, in whole or in part, and provides a new aid in diagnosis. Furthermore, biochemical assay of dopamine, V.M.A., and H.V.A. excretion in urine could perhaps bring information of diagnostic and prognostic value before and after treatment.

• Authors: C Micheau, F Guerinot, C Bohuon, J Brugere
• Journal: Cancer (Cancer) Vol. 35 Issue 5 Pg. 1309-12 (May 1975) ISSN: 0008-543X [Print] United States
• PMID: 1122482 (Publication Type: Journal Article)

Chemical References

• Dopamine beta-Hydroxylase
• Norepinephrine
• Epinephrine

Topics

• Adult
• Antibody Formation
• Dopamine beta-Hydroxylase (metabolism)
• Epinephrine (metabolism)
• Humans
• Male
• Neuroectodermal Tumors, Primitive, Peripheral (metabolism, pathology)
• Norepinephrine (metabolism)
• Nose Neoplasms (enzymology, metabolism, pathology)