Abstract | PURPOSE: METHOD: RESULTS: The mean peak attenuation (A(PA)) of lung adenocarcinoma correlated with MVD (r = 0.689, p < 0.0001). VEGF positiveness of lung adenocarcinoma was 63%. There was a significant difference in A(PA) between VEGF-positive and -negative lung adenocarcinomas (39.9 +/- 3.9 and 24.3 +/- 2.3; p < 0.05). The mean MVDs of VEGF-positive adenocarcinomas were significantly higher than those of negative ones (82.5 +/- 5.9 and 49.2 +/- 7.1; p < 0.05). The mean A(PA) of VEGF-positive lung adenocarcinomas correlated positively with MVD (r = 0.707, p < 0.0001). CONCLUSION: The A(PA) value of dynamic CT reflects MVD in lung adenocarcinoma. The A(PA) value of dynamic CT might be an index for VEGF-related tumor angiogenesis.
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Authors | U Tateishi, H Nishihara, S Watanabe, T Morikawa, K Abe, K Miyasaka |
Journal | Journal of computer assisted tomography
(J Comput Assist Tomogr)
2001 Jan-Feb
Vol. 25
Issue 1
Pg. 23-7
ISSN: 0363-8715 [Print] United States |
PMID | 11176288
(Publication Type: Journal Article)
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Chemical References |
- Endothelial Growth Factors
- Lymphokines
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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Topics |
- Adenocarcinoma
(blood supply, diagnostic imaging, metabolism, pathology)
- Adult
- Aged
- Endothelial Growth Factors
(metabolism, physiology)
- Female
- Humans
- Lung Neoplasms
(blood supply, diagnostic imaging, metabolism, pathology)
- Lymphokines
(metabolism, physiology)
- Male
- Middle Aged
- Neovascularization, Pathologic
(diagnostic imaging, metabolism, pathology)
- Tomography, X-Ray Computed
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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