Abstract | OBJECTIVE: To investigate adult heights attained by patients with 21-hydroxylase deficiency and to perform a meta-analysis of height outcomes reported in this population. STUDY DESIGN: A retrospective chart review of our patients >5 years of age (n = 65) who were followed up from 1978 to 1998 for 21-hydroxylase deficiency was conducted. Final height (FH) SD scores and target height (TH) SD scores were determined. The impact of sex, time of diagnosis, and compliance was assessed. Meta-analysis of results from 18 studies was performed; TH was available for 204 of 561 patients. RESULTS: Mean FH SD score-TH SD score for our 65 patients was -1.03. For the meta-analysis, mean weighted FH SD score for all 561 patients was -1.37, whereas weighted mean FH SD score-TH SD score for the 204 patients for whom TH was available was -1.21. No difference in outcome was seen for males compared with females, although a statistically significant difference was seen for patients identified early versus late. CONCLUSIONS:
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Authors | E A Eugster, L A Dimeglio, J C Wright, G R Freidenberg, R Seshadri, O H Pescovitz |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 138
Issue 1
Pg. 26-32
(Jan 2001)
ISSN: 0022-3476 [Print] United States |
PMID | 11148508
(Publication Type: Journal Article, Meta-Analysis)
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Topics |
- Adrenal Hyperplasia, Congenital
(diagnosis, drug therapy, etiology, psychology)
- Age Factors
- Body Height
(drug effects)
- Child
- Child, Preschool
- Female
- Humans
- Infant
- Infant, Newborn
- Male
- Patient Compliance
(psychology, statistics & numerical data)
- Retrospective Studies
- Severity of Illness Index
- Sex Characteristics
- Time Factors
- Treatment Outcome
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