Abstract | OBJECTIVES: METHODS: A total of 603 patients with endoscopically confirmed (Hetzel-Dent scale) erosive esophagitis of grade 2 (64.5%) or grades 3 or 4 (35.3%) were enrolled in a double-blind, multicenter study and randomly assigned to receive pantoprazole (10 mg, 20 mg, or 40 mg) or placebo, administered once daily in the morning, for 4 or 8 wk depending on healing. RESULTS: The healing rates after 4 wk for placebo and pantoprazole 10 mg, 20 mg, and 40 mg/day were 14%, 42%, 55%, and 72%, respectively (p < 0.001 for all doses of pantoprazole vs placebo). Cumulative healing rates after 8 wk for placebo and pantoprazole 10 mg, 20 mg, and 40 mg/day were 33%, 59%, 78%, and 88%, respectively (p < 0.001 for all doses of pantoprazole vs placebo). The 40-mg pantoprazole dose produced greater rates of healing and earlier healing of esophagitis than either the 10- or 20-mg dose, regardless of severity. Pantoprazole, at any dose, was significantly more effective than placebo in relieving reflux symptoms. Patients on pantoprazole 40 mg experienced relief of symptoms on day 1 of treatment. No serious treatment-related adverse events occurred. CONCLUSIONS:
Pantoprazole was safe and effective for healing erosive esophagitis and provided rapid symptomatic relief. These results indicate that pantoprazole offers a new option for treatment of erosive esophagitis. Among the three doses studied, the 40-mg dose was the most effective.
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Authors | J E Richter, W Bochenek |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 95
Issue 11
Pg. 3071-80
(Nov 2000)
ISSN: 0002-9270 [Print] United States |
PMID | 11095320
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Anti-Ulcer Agents
- Benzimidazoles
- Proton Pump Inhibitors
- Sulfoxides
- Pantoprazole
- Omeprazole
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Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Administration, Oral
- Anti-Ulcer Agents
(administration & dosage, therapeutic use)
- Benzimidazoles
(administration & dosage, therapeutic use)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Esophagitis, Peptic
(drug therapy, etiology)
- Female
- Gastroesophageal Reflux
(complications)
- Humans
- Male
- Middle Aged
- Omeprazole
(analogs & derivatives)
- Pantoprazole
- Proton Pump Inhibitors
- Sulfoxides
(administration & dosage, therapeutic use)
- Time Factors
- United States
- Wound Healing
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