Amantadine monotherapy of chronic hepatitis C patients infected with genotype lb.

Abstract

We aimed to test the efficacy of amantadine in chronic hepatitis C (CHC) patients infected with genotype b. Twenty patients completed treatment with amantadine HCl, 100 mg b.i.d., for 6 months. Non-sustained biochemical improvement was observed without loss of HCV-RNA. We conclude that amantadine monotherapy is not effective in CHC.

• Authors: H Senturk, A Mert, M Akdogan, F Tabak, G Basaran, S Turkoglu, G Ozbay, S Badur
• Journal: Scandinavian journal of infectious diseases (Scand J Infect Dis) Vol. 32 Issue 5 Pg. 575-6 ( 2000) ISSN: 0036-5548 [Print] England
• PMID: 11055673 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• RNA, Viral
• Amantadine

Topics

• Adolescent
• Adult
• Amantadine (therapeutic use)
• Antiviral Agents (therapeutic use)
• Female
• Genotype
• Hepacivirus (classification, genetics)
• Hepatitis C, Chronic (drug therapy, virology)
• Humans
• Male
• Middle Aged
• RNA, Viral (blood)
• Treatment Failure